| 1754 |
Born in New Orleans, the son of Jean-Baptiste Destrehan de Beaupré and Jeanne Catherine Gauvret. He is educated in France. |
| 1771 |
Returns to Louisiana with his brother Jean-Baptiste Destrehan Honoré de Beaupré |
| 1776 |
The brothers purchase a large plantation in St. Charles Parish, but Jean-Baptiste Honoré dies. |
| 1786 |
Marries Marie Claudine Elenore Robin de Logny, daughter of Robert Antoine Robine de Logny and Jeanne Dreux. They will have 14 children, 9 of which survive to adulthood. |
| 1792 December 16 |
Purchases the plantation that will be known as Destrehan Manor from his father-in-law. It will be sold by his widow to son-in-law Stephen Henderson. |
| 1804 |
One of three creoles to protest against provisions of the first Territorial governments. The new government is more liberal allowing election of the lower house of the legislature |
| 1806 |
As a member of the territorial legislative council he becomes president of the council in 1806 and 1811. |
| 1811-1812 |
He opposes statehood, but is a member of the constitutional convention of 1812 |
| 1812 |
Elected to the U. S. Senate, but does not take the seat. |
| 1812-1817 |
Serves in the state senate. |
| 1823 October 8 |
Dies at Destrehan Manor, interred in St. Charles Parish. |
| 1824 |
Destrehan Manor is sold by his widow to son-in-law Stephen Henderson. Henderson’s heirs will sell to Pierre Rost, another son-in-law of Jean Noel Destrehan. |